Publication Archive - Epiconcept

Unmeasured confounding and misclassification in studies estimating vaccine effectiveness against hospitalisation and death using electronic health records (EHRs): an evaluation of a multi-country European retrospective cohort study

Humphreys, James., Nicolay, Nathalie., Braeye, Toon., Van Evercooren, Izaak., Hansen, Christian Holm., Moustsen-Helms, Ida Rask., Sacco, Chiara., Mateo-Urdiales, Alberto., Castilla, Jesús., Martínez-Baz, Iván., Machado, Ausenda., Soares, Patricia., de Gier, Brechje., Meijerink, Hinta., Monge, Susana., Bacci, Sabrina., Nunes, Baltazar

VEBIS-EHR working group, 2025/12/17 - BMC Medical Research Methodology, 1471-2288 - DOI: 10.1186/s12874-025-02742-8

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Protocol to measure COVID-19 XBB.1.5 vaccine effectiveness in the immunocompromised population during the 2023 autumn vaccination campaign

Baltazar Nunes, James Humphreys, Alexandre Blake, Camelia Savulescu, Esther Kissling, Anthony Nardone, Susana Monge Corella, Iván Martínez-Baz, Itziar Casado, Aitziber Echeverría, Camino Trobajo-Sanmartín, Jesús Castilla , Christian Holm Hansen, Ida Rask Moustsen-Helms, Massimo Fabiani, Alberto Mateo Urdiales, Chiara Sacco. Hinta Meijerink, Anja Bråthen Kristoffersen, Patrícia Soares, Ausenda Machado, Rickard Ljung, Nicklas Pihlström

Stockholm, December 2025

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Early estimates of seasonal influenza vaccine effectiveness against influenza requiring medical attention at primary care level in Europe, week 41 – 49, 2025

Kissling E, Lucaccioni H

19 December 2025

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Effectiveness of the 2023 Autumn XBB.1.5 COVID-19 Booster During Summer 2024 in the EU/EEA: A VEBIS Electronic Health Record Network Study

Humphreys J, Nicolay N, Braeye T, Van Evercooren I, Hansen CH, Moustsen-Helms IR, Sacco C, Fabiani M, Castilla J, Martínez-Baz I, Machado A, Soares P, Ljung R, Pihlström N, Kissling E, Nardone A, Monge S, Bacci S, Nunes B; VEBIS‐EHR working group.

2025 Dec;19(12):e70198. doi: 10.1111/irv.70198. PMID: 41312816.

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Recommendations for estimating and reporting vaccine effectiveness by time since vaccination: a COVID-19 case study

Esther Kissling, Baltazar Nunes, Mariëtte Hooiveld, Iván Martínez-Baz, Susana Monge, Chris Robertson, Mirjam Knol, Noémie Sève, Ivan Mlinarić, Lisa Domegan, Ausenda Machado, Heather Whitaker, Mihaela Lazar, Adam Meijer, Theresa Enkirch, Itziar Casado, Gloria Pérez-Gimeno, Naoma William, Vincent Enouf, Sanja Kurečić Filipović, Adele McKenna, Ana Paula Rodrigues, Simon de Lusignan, Olivia-Carmen Timnea, Neus Latorre-Margalef, Jesús Castilla, Francisco Pozo, Mark Hamilton, Shirley Masse, Maja Ilić, Luca Basile, Joan O’Donnell, Raquel Guiomar, Maximilian Riess, Rodica-Manuela Popescu, Angela M C Rose, Nick Andrews, Sabrina Bacci, Lucia Pastore Celentano, Marta Valenciano, Alain Moren, Philippe Beutels, Niel Hens, on behalf of I-MOVE-COVID-19 and ECDC primary care study teams

2025, kwaf254

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Hybrid, infection‑ and vaccination‑induced protection against laboratory‑ confirmedSARS‑CoV‑2 infection in a European multi‑centre prospective cohort of healthcare workers, 2021–2024

Madelyn Rojas-Castro, Ranya Mulchandani, Kim Brolin, Zvjezdana Lovrić Makarić, Anneli Uusküla, Colm Bergin, Catherine Fleming, Paolo Bonfanti, Rita Murri, Viesturs Zvirbulis, Dace Zavadska, Konstanty Szuldrzynski, Vânia Gaio, Corneliu Petru Popescu, Mihai Craiu, Raluca-Maria Hrișcă, Maria Cisneros, Miriam Latorre-Millán, Goranka Petrović, Liss Lohur, Jonathan McGrath, Lauren Ferguson, Anna Spolti, Katleen De Gaetano Donati, Ilze Abolina, Dagne Gravele, Ausenda Machado, Simin Aysel Florescu, Mihaela Lazar, Pilar Subirats, Laura Clusa, Gordan Sarajlić, Jacklyn Sui, Claire Kenny, Rosaria Santangelo, Dainis Krievins, Elza Anna Barzdina, Camila Valadas Henriques, Alma Gabriela Kosa, Săftica-Mariana Pohrib, Victor Daniel Miron, Carmen Muñoz-Almagro, Ana Maria Milagro, Sabrina Bacci, Camelia Savulescu and VEBIS HCW VE study group

DOI: 10.1186/s12916-025-04503-2

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COVID-19 vaccine effectiveness against hospitalisation in older adults, VEBIS hospital network, Europe, September 2024–May 2025

Madelyn Rojas-Castro, Nuno Verdasca, Susana Monge, Laurane De Mot, Camino Trobajo-Sanmartín, Róisín Duffy, Gergő Túri, Monika Kuliese, Ralf Duerrwald, Maria-Louise Borg, Odette Popovici, Verónica Gomez, Zvjezdana Lovrić Makarić, Odile Launay, Diogo F. P. Marques, Francisco Pozo, Arne Witdouck, Iván Martínez-Baz, Margaret Fitzgerald, Beatrix Oroszi, Ligita Jančorienė, Silke Buda, Ausra Dziugyte, Mihaela Lazăr, Ausenda Machado, Irena Tabain, Liem Binh Luong Nguyen, Eva Rivas Wagner, François Dufrasne, Jesús Castilla, Lisa Domegan, Viktória Velkey, Fausta Majauskaite, Carolin Hackmann, Nathalie Nicolay, Sabrina Bacci, Angela M. C. Rose

5 November 2025.

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Effectiveness of long-acting monoclonal antibodies against laboratory-confirmed RSV in children aged < 24 months and hospitalised for severe acute respiratory infection, European pilot study, 2024 to 2025

Camelia Savulescu1,* ORCID icon, Iris Ganser1,* ORCID icon, Nathalie Nicolay2 , Adrien Lajot3 , Sandra Campos4,5 , Iván Martínez-Baz6,7 ORCID icon, Ana Paula Rodrigues8 , Mathil Vandromme3 , Marta Cara-Rodríguez9 , Aitziber Echeverría6,7 ORCID icon, Vânia Gaio8 , Marie-Pierre Parsy10 , Ana Roldan Garrido11 , Jesús Castilla6,7 ORCID icon, Raquel Guiomar12 , Sabrina Bacci2 , Angela MC Rose1 , VEBIS hospital network RSV IE group13

Volume 30, Issue 45, 13/Nov/2025

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Surveillance of severe acute respiratory infections associated with SARS-CoV-2, influenza virus and RSV using ICD-10 codes: a case definition accuracy study across five European countries, 2021 to 2023

Miguel Angel Sanchez Ruiz1 , Diogo FP Marques1 , Frederikke Kristensen Lomholt2 , Lasse Skafte Vestergaard2 , Susana Monge3,4 , Marcos Lozano Álvarez3,5 , Gudrun Aspelund6 , Marianna Thordardottir6 , Ausra Dziugyte7 , John-Paul Cauchi7,8 , Tjarda M Boere9 , Irene K Veldhuijzen9 , Elina Seppälä10 , Håkon Bøås10 , Trine Hessevik Paulsen10 , ESURE SARI group11 , Ausenda Machado12 , Ana Paula Rodrigues12 , Mariette Hooiveld13 , Luis Alves de Sousa14 , Ana Torres14 , Carlos Carvalho14 , Baltazar Nunes1

Volume 30, Issue 27, 10/Jul/2025

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Effectiveness of JN.1 monovalent COVID-19 vaccination in EU/EEA countries between October 2024 and January 2025: a VEBIS electronic health record network study

James Humphreys a, Alexandre Blake a, Nathalie Nicolay b, Toon Braeye c, Izaak Van Evercooren c, Christian Holm Hansen d, Ida Rask Moustsen-Helms d, Chiara Sacco e f, Alberto Mateo-Urdiales e, Jesús Castilla g h, Iván Martínez-Baz g h, Ausenda Machado i, Andre Brito i, Rickard Ljung j k, Nicklas Pihlstrom j k, Yohann Mansiaux a, Susana Monge l m, Sabrina Bacci b, Baltazar Nunes a, VEBIS-EHR working group 1

Vaccine 64 (2025) 127752

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