Vaccine Effectiveness, Burden and Impact Studies (VEBIS) of COVID-19 and Influenza

Project description

The objectives of the project is to provide technical support to the European Centre for Disease Prevention and Control to build an infrastructure to allow regular monitoring of COVID-19 and influenza vaccine effectiveness over time, using a multi-country approach. The VEBIS platform includes vaccine effectiveness studies implemented in different settings.

Context situation

Vaccination plays a key role in the control of the coronavirus disease (COVID-19) pandemic and the lifting of some non-pharmaceutical interventions. Assessment of the real-world performance of the vaccines in the European Union is important to be able to adapt to European vaccination strategies.

Project activities

Hospital network measuring influenza and COVID-19 vaccine effectiveness

Multicentre test-negative design study.

Vaccine effectiveness and impact of COVID-19

vaccines through routinely collected exposure and outcome data using health registries.

COVID-19 vaccine effectiveness against SARS-CoV-2 infection among healthcare workers

Multicentre cohort study.

Primary care network measuring influenza and COVID-19 vaccine effectiveness

Multicentre test-negative design study.

Scientific publications

Effectiveness of the XBB.1.5 COVID-19 Vaccines Against SARS-CoV-2 Hospitalisation Among Adults Aged ≥ 65 Years During the BA.2.86/JN.1 Predominant Period, VEBIS Hospital Study, Europe, November 2023 to May 2024

Antunes L, Rojas-Castro M, Lozano M, Martínez-Baz I, Leroux-Roels I, Borg ML, Oroszi B, Fitzgerald M, Dürrwald R, Jancoriene L, Machado A, Petrović G, Lazar M, Součková L, Bacci S, Howard J, Verdasca N, Basile L, Castilla J, Ternest S, Džiugytė A, Túri G, Duffy R, Hackmann C, Kuliese M, Gomez V, Makarić ZL, Marin A, Husa P, Nicolay N, Rose AMC; VEBIS SARI VE network team.

2025 Mar;19(3):e70081. doi: 10.1111/irv.70081. PMID: 40059069; PMCID: PMC11890973.

Relative effectiveness of the second booster COVID-19 vaccines against laboratory confirmed SARS-CoV-2 infection in healthcare workers: VEBIS HCW VE cohort study (1 October 2022-2 May 2023)

Camelia Savulescu, Albert Prats-Uribe, Kim Brolin, Anneli Uusküla, Colm Bergin, Catherine Fleming, Viesturs Zvirbulis, Dace Zavadska, Konstanty Szułdrzyński, Vânia Gaio, Corneliu Petru Popescu, Mihai Craiu, Maria Cisneros, Miriam Latorre-Millán, Liis Lohur, Jonathan McGrath, Lauren Ferguson, Ilze Abolina, Dagne Gravele, Ausenda Machado, Simin Aysel Florescu, Mihaela Lazar, Pilar Subirats, Laura Clusa Cuesta, Jacklyn Sui, Claire Kenny, Dainis Krievins, Elza Anna Barzdina, Aryse Melo, Alma Gabriela Kosa, Victor Daniel Miron, Carmen Muñoz-Almagro, Ana María Milagro, Sabrina Bacci, Piotr Kramarz, Anthony Nardone.

Vaccine, Volume 45, 2025, 126615, ISSN 0264-410X

COVID-19 vaccine effectiveness in the paediatric population aged 5–17 years: a multicentre cohort study using electronic health registries in six European countries, 2021 to 2022

Soares Patrícia, Machado Ausenda, Nicolay Nathalie, Monge Susana, Sacco Chiara, Hansen Christian Holm, Meijerink Hinta, Martínez-Baz Iván, Schmitz Susanne, Humphreys James, Fabiani Massimo, Echeverria Aitziber, AlKerwi Ala’a, Nardone Anthony, Mateo-Urdiales Alberto, Castilla Jesús, Kissling Esther, Nunes Baltazar, VEBIS-Lot 4 working group.

Euro Surveill. 2025;30(8):pii=2400450.

Interim 2024/25 influenza vaccine effectiveness: eight European studies, September 2024 to January 2025

Rose Angela MC, Lucaccioni Héloïse, Marsh Kimberly, Kirsebom Freja, Whitaker Heather, Emborg Hanne-Dorthe, Bolt Botnen Amanda, O’Doherty Mark G, Pozo Francisco, Hameed Safraj Shahul, Andrews Nick, Hamilton Mark, Trebbien Ramona, Lauenborg Møller Karina, Marques Diogo FP, Murphy Siobhan, McQueenie Ross, Lopez-Bernal Jamie, Cottrell Simon, Bucholc Magda, Kissling Esther, European IVE group.

Euro Surveill. 2025;30(7):pii=2500102.

Core protocol for ECDC studies of COVID-19 vaccine effectiveness against hospitalisation with Severe Acute Respiratory Infection, laboratory-confirmed with SARS-CoV-2 or with seasonal influenza – Version 2.0.

Jenny Howard, Esther Kissling, Ruoran Li, Alain Moren, Anthony Nardone, Angie Rose, Marta Valenciano (Epiconcept)

Stockholm: ECDC, January 2023.

COVID-19 vaccine effectiveness against hospitalisation and death using electronic health records in eight European countries in the VEBIS monitoring network

Susana Monge Corella (Instituto de Salud Carlos III, Spain), Baltazar Nunes, James Humphreys, Anthony Nardone, Esther Kissling, (Epiconcept, France), Diana Lucas Almeida, Patricia Soares, Ausenda Machado (Instituto Nacional de Saúde, Portugal), Itziar Casado, Jesús Castilla, Iván Martínez-Baz, Aitziber Echeverria (Instituto de Salud Pública y Laboral de Navarra – IdiSNA – CIBERESP, Spain), Hanne-Dorthe Emborg, Katrin Finderup, Christian Holm Hansen, Bolette Søborg, Palle Valentiner-Branth (Statens Serum Institut, Denmark), Hinta Meijerink, Anja Kristoffersen, Jostein Starrfelt (Norwegian Institute of Public Health), Toon Braeye, Izaak Van Evercooren, Joris Van Loenhout (Epidemiology of infectious diseases, Sciensano, Brussels, Belgium), Ala’a AlKerwi, Susanne Schmitz (Ministry of Health and social security, Directorate of Health, Service epidemiology and statistics, Luxembourg), Chiara Sacco, Alberto Mateo Urdiales, Massimo Fabiani (Istituto Superiore di Sanità, Italy), Brechje de Gier, Susan Hahné (Dutch National Institute for Public Health and the Environment – RIVM, the Netherlands), Rickard Ljung, Nicklas Pihlström, (Swedish Medical Products Agency, Uppsala, Sweden)

Stockholm: ECDC; 2024

Core protocol for ECDC studies of vaccine effectiveness against hospitalisation with Severe Acute Respiratory Infection, laboratory-confirmed with SARS-CoV-2 or with seasonal influenza

Liliana Antunes, Jenny Howard, Esther Kissling, Ruoran Li, Alain Moren, Anthony Nardone, Angie Rose, Marta Valenciano

Version 4.0 - 17 Dec 2024

Incidence of SARS-CoV-2 Infection Among European Healthcare Workers and Effectiveness of the First Booster COVID-19 Vaccine, VEBIS HCW Observational Cohort Study, May 2021–May 2023

Savulescu, C., Prats-Uribe, A., Brolin, K., Lovrić Makarić, Z., Uusküla, A., Panagiotakopoulos, G., Bergin, C., Fleming, C., Agodi, A., Bonfanti, P., Murri, R., Zvirbulis, V., Zavadska, D., Szuldrzynski, K., Machado, A., Popescu, C. P., Craiu, M., Cisneros, M., Latorre-Millán, M., … the VEBIS HCW VE Study Group. (2024).

Vaccines, 12(11), 1295.

Generic protocol for ECDC studies of COVID-19 vaccine effectiveness against confirmed SARS-CoV-2 using healthcare worker cohorts, version 3.0

Camelia Savulescu, Esther Kissling, Anthony Nardone (Epiconcept)

Stockholm: ECDC; 2024.

The Potential Bias Introduced into COVID-19 Vaccine Effectiveness Studies at Primary Care Level Due to the Availability of SARS-CoV-2 Tests in the General Population

Lanièce Delaunay, Charlotte and Nunes, Baltazar and Monge, Susana and de Lange, Marit and Túri, Gergő and Machado, Ausenda and Latorre-Margalef, Neus and Mlinarić, Ivan and Lazar, Mihaela and Botella Rocamora, Paloma and Erdwiens, Annika and Sève, Noémie and Domegan, Lisa and Martínez-Baz, Iván and Hooiveld, Mariëtte and Oroszi, Beatrix and Guiomar, Raquel and Sperk, Maike and Kurečić Filipović, Sanja and Pascu, Catalina and Linares Dopido, Juan Antonio and Dürrwald, Ralf and Rameix-Welti, Marie-Anne and McKenna, Adele and Castilla, Jesús and van Hagen, Cheyenne and Knol, Mirjam J. and Bacci, Sabrina and Kaczmarek, Marlena and Kissling, Esther

Available at SSRN: https://ssrn.com/abstract=5014164

Interim analysis of COVID-19 vaccine effectiveness against hospitalisation and death in eight European countries using electronic health records: first update

Susana Monge Corella, Mario Fontán-Vela (Instituto de Salud Carlos III, Spain), Anthony Nardone, Alexis Sentís, Esther Kissling, James Humphreys Baltazar Nunes (Epiconcept, France), Irina Kislaya, Constantino Caetano, Patricia Soares, Ausenda Machado (Instituto Nacional de Saúde, Portugal), Itziar Casado, Jesús Castilla, Iván Martínez-Baz, Aitziber Echeverria (Instituto de Salud Pública y Laboral de Navarra – IdiSNA – CIBERESP, Spain), Hanne-Dorthe Emborg, Katrin Finderup, Christian Holm Hansen, Bolette Søborg, Palle Valentiner-Branth (Statens Serum Institut, Denmark), Hinta Meijerink, Anja Kristoffersen, Jostein Starrfelt (Norwegian Institute of Public Health), Toon Braeye, Izaak Van Evercooren, Joris Van Loenhout, Pierre Hubin (Epidemiology of infectious diseases, Sciensano, Brussels, Belgium), Ala’a AlKerwi, Susanne Schmitz (Ministry of Health and Social Security, Directorate of Health, Service Epidemiology and Statistics, Luxembourg), Chiara Sacco, Alberto Mateo Urdiales, Massimo Fabiani (Istituto Superiore di Sanità, Italy), Brechje de Gier, Susan Hahné (Dutch National Institute for Public Health and the Environment – RIVM – the Netherlands).

first update. Stockholm: ECDC; 2024.

Effectiveness of XBB.1.5 Monovalent COVID-19 Vaccines During a Period of XBB.1.5 Dominance in EU/EEA Countries, October to November 2023: A VEBIS-EHR Network Study

Susana Monge, James Humphreys, Nathalie Nicolay, Toon Braeye, Izaak Van Evercooren, Christian Holm Hansen, Hanne-Dorthe Emborg, Chiara Sacco, Alberto Mateo-Urdiales, Jesús Castilla, Iván Martínez-Baz, Brechje de Gier, Susan Hahné, Hinta Meijerink, Anja Bråthen Kristoffersen, Ausenda Machado, Patricia Soares, Anthony Nardone, Sabrina Bacci, Esther Kissling, Baltazar Nunes, VEBIS-EHR Working Group

Protocol for a COVID-19 vaccine effectiveness multi-country cohort study in the paediatric population aged 5–17-years using electronic health records in EU/EEA countries

Baltazar Nunes, Anthony Nardone, Alexis Sentis, Esther Kissling, James Humphreys

Monovalent XBB.1.5 COVID-19 vaccine effectiveness against hospitalisations and deaths during the omicron BA.2.86/JN.1 period among older adults in seven European countries: a VEBIS-EHR network study

Nunes B, Humphreys J, Nicolay N, Braeye T, Van Evercooren I, Holm Hansen C, Moustsen-Helms IR, Sacco C, Fabiani M, Castilla J, Martínez-Baz I, Meijerink H, Machado A, Soares P, Ljung R, Pihlström N, Nardone A, Bacci S, Monge S; VEBIS-EHR working group; VEBIS EHR working group names

Expert Rev Vaccines. 2024 Nov 13. doi: 10.1080/14760584.2024.2428800doi:10.1080/14760584.2024.2428800.

Effectiveness of XBB.1.5 Vaccines Against Symptomatic SARS-CoV-2 Infection in Older Adults During the JN.1 Lineage-Predominant Period, European VEBIS Primary Care Multicentre Study, 20 November 2023–1 March 2024

Merdrignac, Lore and Lanièce Delaunay, Charlotte and Verdasca, Nuno and Vega-Pirisc, Lorena and O’Donnell, Joan and Sève, Noémie and Trobajo-Sanmartín, Camino and Buda, Silke and Hooiveld, Mariëtte and Rodrigues, Ana Paula and Túri, Gergő and Latorre-Margalef, Neus and Mlinarić, Ivan and Lazarm, Mihaela and Maurel, Marine and Castrillejo, Daniel and Bennett, Charlene and Rameix Welti, Marie-Anne and Martínez-Baz, Iván and Dürrwald, Ralf and Meijer, Adam and Melo, Aryse and Oroszi, Beatrix and Samuelsson Hagey, Tove and Kurečić Filipović, Sanja and Dijkstra, Frederika and Gomez, Verónica and Bacci, Sabrina and Kaczmarek, Marlena and Kissling, Esther

Influenza Other Respi Viruses, 18: e70009.

Effectiveness of the autumn 2023 COVID-19 vaccine dose in hospital-based healthcare workers: results of the VEBIS healthcare worker vaccine effectiveness cohort study, seven European countries, season 2023/24

Savulescu Camelia, Prats-Uribe Albert, Brolin Kim, Uusküla Anneli, Bergin Colm, Fleming Catherine, Murri Rita, Zvirbulis Viesturs, Zavadska Dace, Gaio Vania, Popescu Corneliu P, Hrisca Raluca, Cisneros Maria, Latorre-Millán Miriam, Lohur Liis, McGrath Jonathan, Ferguson Lauren, De Gaetano Donati Katleen, Abolina Ilze, Gravele Dagne, Machado Ausenda, Florescu Simin-Aysel, Lazar Mihaela, Subirats Pilar, Clusa Cuesta Laura, Sui Jacklyn, Kenny Claire, Santangelo Rosaria, Krievins Dainis, Barzdina Elza Anna, Valadas Henriques Camila, Kosa Alma Gabriela, Pohrib Saftica-Mariana, Muñoz-Almagro Carmen, Milagro Ana, Bacci Sabrina, Nardone Anthony, VEBIS HCW VE study group.

Euro Surveill. 2024;29(44):pii=2400680

Early COVID-19 XBB.1.5 Vaccine Effectiveness Against Hospitalisation Among Adults Targeted for Vaccination, VEBIS Hospital Network, Europe, October 2023–January 2024

Antunes L, Mazagatos C, Martínez-Baz I, Naesens R, Borg ML, Petrović G, Fatukasi T, Jancoriene L, Machado A, Oroszi B, Husa P, Lazar M, Dürrwald R, Howard J, Melo A, Pérez-Gimeno G, Castilla J, Bernaert E, Džiugytė A, Makarić ZL, Fitzgerald M, Mickienė A, Gomez V, Túri G, Součková L, Marin A, Tolksdorf K, Nicolay N, Rose AMC European Hospital Vaccine Effectiveness Group

Aug;18(8):e13360. doi: 10.1111/irv.13360. PMID: 39145535; PMCID: PMC11325250.

COVID-19 Vaccine Effectiveness in Autumn and Winter 2022 to 2023 Among Older Europeans

Charlotte Laniece Delaunay, PhD1; Clara Mazagatos, PhD2,3; Iván Martínez-Baz, PhD4; Gergő Túri, MSc5; Luise Goerlitz, MSc6; Lisa Domegan, PhD7; Adam Meijer, PhD8; Ana Paula Rodrigues, MSc9; Noémie Sève, MSc10; Maja Ilić, MD11; Neus Latorre-Margalef, PhD12; Mihaela Lazar, PhD13; Marine Maurel, MSc1; Aryse Melo, PhD14; Blanca Andreu Ivorra, MD, PhD15; Itziar Casado, MD, PhD4; Judit Krisztina Horváth, MD5; Silke Buda, MD6; Charlene Bennett, PhD16; Marit de Lange, PhD8; Raquel Guiomar, MSc14; Vincent Enouf, PhD17; Ivan Mlinarić, MD11; Tove Samuelsson Hagey, MSc12; Sorin Dinu, PhD13; Mercedes Rumayor, MD, PhD18; Jesús Castilla, MD, PhD4; Beatrix Oroszi, PhD5; Ralf Dürrwald, MD19; Joan O’Donnell, MB, MFPHMI7; Mariëtte Hooiveld, PhD20; Verónica Gomez, MSc9; Alessandra Falchi, PhD21; Sanja Kurečić Filipović, MD, PhD11; Lena Dillner, MD, PhD12; Rodica Popescu, MD22; Sabrina Bacci, MD23; Marlena Kaczmarek, PhD23; Esther Kissling, MSc1; for the VEBIS Primary Care Vaccine Effectiveness Group

JAMA Netw Open. 2024;7(7):e2419258. doi:10.1001/jamanetworkopen.2024.19258

Exploring the effect of clinical case definitions on influenza vaccine effectiveness estimation at primary care level: Results from the end-of-season 2022-23 VEBIS multicentre study in Europe

Maurel M, Mazagatos C, Goerlitz L, Oroszi B, Hooiveld M, Machado A, Domegan L, Ilić M, Popescu R, Sève N, Martínez-Baz I, Larrauri A, Buda S, Túri G, Meijer A, Gomez V, O’Donnell J, Mlinarić I, Timnea O, Diez AO, Dürrwald R, Horváth JK, Dijkstra F, Rodrigues AP, McKenna A, Filipović SK, Lazar M, Kaczmarek M, Bacci S, Kissling E; VEBIS study team.

Vaccine. 2024 Jun 11;42(16):3547-3554. doi: 10.1016/j.vaccine.2024.04.060. Epub 2024 May 3. PMID: 38704257; PMCID: PMC11152456.

Effectiveness of COVID-19 vaccines administered in the 2023 autumnal campaigns in Europe: Results from the VEBIS primary care test-negative design study, September 2023–January 2024

Laniece Delaunay C, Melo A, Maurel M, Mazagatos C, Goerlitz L, O’Donnell J, Oroszi B, Sève N, Rodrigues AP, Martínez-Baz I, Meijer A, Mlinarić I, Latorre-Margalef N, Lazăr M, Pérez-Gimeno G, Dürrwald R, Bennett C, Túri G, Rameix-Welti MA, Guiomar R, Castilla J, Hooiveld M, Kurečić Filipović S, Samuelsson Hagey T, Dijkstra F, Borges V, Ramos Marín V, Bacci S, Kaczmarek M, Kissling E; European primary care VE group.

2024 Jun 4:S0264-410X(24)00644-3. doi: 10.1016/j.vaccine.2024.05.067. Epub ahead of print. PMID: 38839521.

COVID-19 vaccine effectiveness against symptomatic infection with SARS-CoV-2 BA.1/BA.2 lineages among adults and adolescents in a multicentre primary care study, Europe, December 2021 to June 2022

Lanièce Delaunay Charlotte, Martínez-Baz Iván, Sève Noémie, Domegan Lisa, Mazagatos Clara, Buda Silke, Meijer Adam, Kislaya Irina, Pascu Catalina, Carnahan AnnaSara, Oroszi Beatrix, Ilić Maja, Maurel Marine, Melo Aryse, Sandonis Martín Virginia, Trobajo-Sanmartín Camino, Enouf Vincent, McKenna Adele, Pérez-Gimeno Gloria, Goerlitz Luise, de Lange Marit, Rodrigues Ana Paula, Lazar Mihaela, Latorre-Margalef Neus, Túri Gergő, Castilla Jesús, Falchi Alessandra, Bennett Charlene, Gallardo Virtudes, Dürrwald Ralf, Eggink Dirk, Guiomar Raquel, Popescu Rodica, Riess Maximilian, Horváth Judit Krisztina, Casado Itziar, García Mª del Carmen, Hooiveld Mariëtte, Machado Ausenda, Bacci Sabrina, Kaczmarek Marlena, Kissling Esther, on behalf of the European Primary Care Vaccine Effectiveness Group.

Euro Surveill. 2024;29(13):pii=2300403.

Vaccine effectiveness against influenza hospitalisation in adults during the 2022/2023 mixed season of influenza A(H1N1)pdm09, A(H3N2) and B circulation, Europe: VEBIS SARI VE hospital network

Angela M. C. Rose, Francisco Pozo, Iván Martínez-Baz, Clara Mazagatos, Nathalie Bossuyt, John Paul Cauchi, Goranka Petrović, Isabela I. Loghin, Roberta Vaikutyte, Silke Buda, Ausenda Machado, Róisín Duffy, Beatrix Oroszi, Jennifer Howard, Aitziber Echeverria, Cristina Andreu, Cyril Barbezange, Aušra Džiugytė, Diana Nonković, Corneliu-Petru Popescu, Fausta Majauskaite, Kristin Tolksdorf, Verónica Gomez, Lisa Domegan, Judit Krisztina Horváth, Jesús Castilla, Miriam García, Thomas Demuyser, Maria-Louise Borg, Irena Tabain, Mihaela Lazar, Ieva Kubiliute, Ralf Dürrwald, Raquel Guiomar, Joan O’Donnell, Katalin Kristóf, Nathalie Nicolay, Sabrina Bacci, Esther Kissling, VEBIS SARI VE network team

Influenza Other Respi Viruses. 2024; 18(2):e13255. doi:10.1111/irv.13255

Interim 2023/24 influenza A vaccine effectiveness: VEBIS European primary care and hospital multicentre studies, September 2023 to January 2024

Maurel Marine, Howard Jennifer, Kissling Esther, Pozo Francisco, Pérez-Gimeno Gloria, Buda Silke, Sève Noémie, McKenna Adele, Meijer Adam, Rodrigues Ana Paula, Martínez-Baz Iván, Mlinarić Ivan, Latorre-Margalef Neus, Túri Gergő, Lazăr Mihaela, Mazagatos Clara, Echeverria Aitziber, Abela Stephen, Bourgeois Marc, Machado Ausenda, Dürrwald Ralf, Petrović Goranka, Oroszi Beatrix, Jancoriene Ligita, Marin Alexandru, Husa Petr, Duffy Roisin, Dijkstra Frederika, Gallardo García Virtudes, Goerlitz Luise, Enouf Vincent, Bennett Charlene, Hooiveld Mariëtte, Guiomar Raquel, Trobajo-Sanmartín Camino, Višekruna Vučina Vesna, Samuelsson Hagey Tove, Lameiras Azevedo Ana Sofía, Castilla Jesús, Xuereb Gerd, Delaere Bénédicte, Gómez Verónica, Tolksdorf Kristin, Bacci Sabrina, Nicolay Nathalie, Kaczmarek Marlena, Rose Angela MC, on behalf of the European IVE group.

Euro Surveill. 2024;29(8):pii=2400089.

Protocol for a COVID-19 vaccine effectiveness study using health data registries, v.2.0

Susana Monge Corella, Mario Fontán Vela (Instituto de Salud Carlos III, Spain), Irina Kislaya, Baltazar Nunes,
Ausenda Machado, Patricia Soares and Constantino Caetano (Instituto Nacional de Saúde, Portugal), Cristina
Buguri, Itziar Casado, Jesús Castilla, Iván Martínez-Baz (Instituto de Salud Pública y Laboral de Navarra), HanneDorthe Emborg, Katrin Finderup, Christian Holm Hansen, Bolette Søborg, Palle Valentiner-Branth (Statens Serum
Institut, Denmark), Jostein Starrfelt, Hinta Meijerink, Anja Bråthen Kristoffersen (Norwegian Institute of Public
Health), Joris van Loenhout, Toon Braeye, Izaak Van Evercooren, Pierre Hubin (Sciensano, Belgium), Brechje de
Gier, Susan Hahné (Dutch National Institute for Public Health and the Environment – RIVM-, the Netherlands), Ala’a
AlKerwi, Susanne Schmitz (Ministry of Health, Directorate of Health, Service epidemiology and statistics,
Luxembourg), Chiara Sacco, Alberto Mateo Urdiales, and Massimo Fabiani (Istituto Superiore di Sanità, Italy),
Anthony Nardone, Alexis Sentís, Esther Kissling, James Humphreys, Marta Valenciano (Epiconcept, France).

European Centre for Disease Prevention and Control. Stockholm: ECDC; 2024

Core protocol for ECDC studies of COVID-19 vaccine effectiveness against hospitalisation with Severe Acute Respiratory Infection, laboratory-confirmed with SARS-CoV-2 or with seasonal influenza – Version 3.0

Liliana Antunes, Jenny Howard, Esther Kissling, Ruoran Li, Alain Moren, Anthony Nardone, Angie Rose, Marta Valenciano

ECDC - Version 3.0

Effectiveness of the adapted bivalent mRNA COVID-19 vaccines against hospitalisation in individuals aged ≥ 60 years during the Omicron XBB lineage-predominant period: VEBIS SARI VE network, Europe, February to August, 2023

Antunes Liliana, Mazagatos Clara, Martínez-Baz Iván, Gomez Verónica, Borg Maria-Louise, Petrović Goranka, Duffy Róisín, Dufrasne François E, Dürrwald Ralf, Lazar Mihaela, Jancoriene Ligita, Oroszi Beatrix, Husa Petr, Howard Jennifer, Melo Aryse, Pozo Francisco, Pérez-Gimeno Gloria, Castilla Jesús, Machado Ausenda, Džiugytė Aušra, Karabuva Svjetlana, Fitzgerald Margaret, Fierens Sébastien, Tolksdorf Kristin, Popovici Silvia-Odette, Mickienė Auksė, Túri Gergő, Součková Lenka, Nicolay Nathalie, Rose Angela MC, on behalf of the European Hospital Vaccine Effectiveness Group.

Euro Surveill. 2024;29(3):pii=2300708.

Generic protocol for ECDC studies of COVID-19 vaccine effectiveness against confirmed SARS-CoV-2 using healthcare worker cohorts, v.2.0

Camelia Savulescu, Esther Kissling, Anthony Nardone

Stockholm: ECDC; 2022.

Generic protocol for ECDC studies of influenza vaccine effectiveness against confirmed infection using healthcare worker cohorts – version 2.0

Camelia Savulescu, Esther Kissling, Anthony Nardone

European Centre for Disease Prevention and Control. Stockholm: ECDC; 2024.

Relative vaccine effectiveness against COVID-19 hospitalisation in persons aged ≥ 65 years: results from a VEBIS network, Europe, October 2021 to July 2023

Fontán-Vela Mario, Kissling Esther, Nicolay Nathalie, Braeye Toon, Van Evercooren Izaak, Holm Hansen Christian, Emborg Hanne-Dorthe, Fabiani Massimo, Mateo-Urdiales Alberto, AlKerwi Ala’a, Schmitz Susanne, Castilla Jesús, Martínez-Baz Iván, de Gier Brechje, Hahné Susan, Meijerink Hinta, Starrfelt Jostein, Nunes Baltazar, Caetano Constantino, Derrough Tarik, Nardone Anthony, Monge Susana, VEBIS-Lot4 working group.

Euro Surveill. 2024;29(1):pii=2300670

Influenza vaccine effectiveness in Europe: Results from the 2022–2023 VEBIS (Vaccine Effectiveness, Burden and Impact Studies) primary care multicentre study

Maurel M, Pozo F, Pérez-Gimeno G, et al.

Influenza Other Respi Viruses. 2024; 18(1):e13243. doi:10.1111/irv.13243

Vaccine effectiveness against COVID-19 hospitalisation in adults (≥ 20 years) during Omicron-dominant circulation: I-MOVE-COVID-19 and VEBIS SARI VE networks, Europe, 2021 to 2022

Rose AM, Nicolay N, Sandonis Martín V, Mazagatos C, Petrović G, Baruch J, Denayer S, Seyler L, Domegan L, Launay O, Machado A, Burgui C, Vaikutyte R, Niessen FA, Loghin II, Husa P, Aouali N, Panagiotakopoulos G, Tolksdorf K, Horváth JK, Howard J, Pozo F, Gallardo V, Nonković D, Džiugytė A, Bossuyt N, Demuyser T, Duffy R, Luong Nguyen LB, Kislaya I, Martínez-Baz I, Gefenaite G, Knol MJ, Popescu C, Součková L, Simon M, Michelaki S, Reiche J, Ferenczi A, Delgado-Sanz C, Lovrić Makarić Z, Cauchi JP, Barbezange C, Van Nedervelde E, O’Donnell J, Durier C, Guiomar R, Castilla J, Jonikaite I, Bruijning-Verhagen PC, Lazar M, Demlová R, Wirtz G, Amerali M, Dürrwald R, Kunstár MP, Kissling E, Bacci S, Valenciano M; I-MOVE-COVID-19 hospital study team; VEBIS hospital study team; Members of the I-MOVE-COVID-19 and VEBIS hospital study teams (in addition to authors above)

Euro Surveill. 2023 Nov;28(47):2300187. doi: 10.2807/1560-7917.ES.2023.28.47.2300187. PMID: 37997665; PMCID: PMC10668256.

Vaccine effectiveness against COVID-19 hospitalisation in adults (≥ 20 years) during Alpha- and Delta-dominant circulation: I-MOVE-COVID-19 and VEBIS SARI VE networks, Europe, 2021

Rose AM, Nicolay N, Sandonis Martín V, Mazagatos C, Petrović G, Niessen FA, Machado A, Launay O, Denayer S, Seyler L, Baruch J, Burgui C, Loghin II, Domegan L, Vaikutytė R, Husa P, Panagiotakopoulos G, Aouali N, Dürrwald R, Howard J, Pozo F, Sastre-Palou B, Nonković D, Knol MJ, Kislaya I, Luong Nguyen LB, Bossuyt N, Demuyser T, Džiugytė A, Martínez-Baz I, Popescu C, Duffy R, Kuliešė M, Součková L, Michelaki S, Simon M, Reiche J, Otero-Barrós MT, Lovrić Makarić Z, Bruijning-Verhagen PC, Gomez V, Lesieur Z, Barbezange C, Van Nedervelde E, Borg ML, Castilla J, Lazar M, O’Donnell J, Jonikaitė I, Demlová R, Amerali M, Wirtz G, Tolksdorf K, Valenciano M, Bacci S, Kissling E; I-MOVE-COVID-19 hospital study team; VEBIS hospital study team; Members of the I-MOVE-COVID-19 and VEBIS hospital study teams (in addition to the named authors)

Euro Surveill. 2023 Nov;28(47):2300186. doi: 10.2807/1560-7917.ES.2023.28.47.2300186. PMID: 37997666; PMCID: PMC10668259.

Monitoring COVID-19 vaccine effectiveness against COVID-19 hospitalisation and death using electronic health registries in ≥65 years old population in six European countries, October 2021 to November 2022

Kislaya I, Sentís A, Starrfelt J, Nunes B, Martínez-Baz I, Nielsen KF, AlKerwi A, Braeye T, Fontán-Vela M, Bacci S, Meijerink H, Castilla J, Emborg HD, Hansen CH, Schmitz S, Van Evercooren I, Valenciano M, Nardone A, Nicolay N, Monge S; VEBIS‐Lot4 working group.

Influenza Other Respir Viruses. 2023 Nov;17(11):e13195. doi: 10.1111/irv.13195. PMID: 38019704; PMCID: PMC10682901.

Interim analysis of COVID-19 vaccine effectiveness against Severe Acute Respiratory Infection due to SARS-CoV-2 in individuals aged 20 years and older – fourth update

Jennifer Howard, Esther Kissling, Ruoran Li, Anthony Nardone, Angie Rose (Epiconcept)

ECDC: Stockholm; 2023 March, 16

Core protocol for ECDC studies of COVID-19 vaccine effectiveness against hospitalisation with Severe Acute Respiratory Infection, laboratoryconfirmed with SARS-CoV-2 or with seasonal influenza – Version 2.0

Jenny Howard, Esther Kissling, Ruoran Li, Alain Moren, Anthony Nardone, Angie Rose, Marta Valenciano (Epiconcept)

Stockholm: ECDC; 2023. January

European Centre for Disease Prevention and Control. Interim analysis of COVID-19 vaccine effectiveness against Severe Acute Respiratory Infection due to laboratory-confirmed SARS-CoV-2 among individuals aged 20 years and older, ECDC multi-country study – third update

European Centre for Disease Prevention and Control: Sabrina Bacci, Nathalie Nicolay.
Epiconcept, Paris, France: Jennifer Howard, Esther Kissling, Anthony Nardone, Angie Rose

ECDC: Stockholm; 2022 November 8.

COVID-19 vaccine effectiveness among healthcare workers in Albania (COVE-AL): protocol for a prospective cohort study and cohort baseline data.

Sridhar S, Fico A, Preza I, Hatibi I, Sulo J, Kissling E, Daja R, Ibrahim R, Lemos D, Rubin-Smith J, Schmid A, Vasili A, Valenciano M, Jorgensen P, Pebody R, Lafond KE, Katz MA, Bino S.

BMJ Open 2022;12:e057741. doi: 10.1136/bmjopen-2021-057741

Effectiveness of complete primary vaccination against COVID-19 at primary care and community level during predominant Delta circulation in Europe: multicentre analysis, I-MOVE-COVID-19 and ECDC networks, July to August 2021.

Kissling Esther, Hooiveld Mariëtte, Martínez-Baz Iván, Mazagatos Clara, William Naoma, Vilcu Ana-Maria, Kooijman Marjolein N, Ilić Maja, Domegan Lisa, Machado Ausenda, de Lusignan Simon, Lazar Mihaela, Meijer Adam, Brytting Mia, Casado Itziar, Larrauri Amparo, Murray Josephine-L K, Behillil Sylvie, de Gier Brechje, Mlinarić Ivan, O’Donnell Joan, Rodrigues Ana Paula, Tsang Ruby, Timnea Olivia, de Lange Marit, Riess Maximilian, Castilla Jesús, Pozo Francisco, Hamilton Mark, Falchi Alessandra, Knol Mirjam J, Kurečić Filipović Sanja, Dunford Linda, Guiomar Raquel, Cogdale Jade, Cherciu Carmen, Jansen Tessa, Enkirch Theresa, Basile Luca, Connell Jeff, Gomez Verónica, Sandonis Martín Virginia, Bacci Sabrina, Rose Angela MC, Pastore Celentano Lucia, Valenciano Marta, I-MOVE-COVID-19 and ECDC primary care study teams.

Euro Surveill. 2022;27(21):pii=2101104.

European Centre for Disease Prevention and Control. Interim analysis of COVID-19 vaccine effectiveness against Severe Acute Respiratory Infection due to laboratory-confirmed SARS-CoV-2 among individuals aged 50 years and older, ECDC multi-country study – first update.

European Centre for Disease Prevention and Control.

ECDC: Stockholm; 2022 January 20

Estimation of COVID-19 vaccine effectiveness against hospitalisation in individuals aged ≥ 65 years using electronic health registries; a pilot study in four EU/EEA countries, October 2021 to March 2022

Sentís A, Kislaya I, Nicolay N, Meijerink H, Starrfelt J, Martínez-Baz I, Castilla J, Nielsen KF, Hansen CH, Emborg HD, Nardone A, Derrough T, Valenciano M, Nunes B, Monge S, the VEBIS-Lot4 working group

October 2021 to March 2022. Euro Surveill. 2022;27(30):pii=2200551

European Centre for Disease Prevention and Control. Interim analysis of COVID-19 vaccine effectiveness against Severe Acute Respiratory Infection due to laboratory-confirmed SARS-CoV-2 among individuals aged 30 years and older, ECDC multi-country study – second update.

European Centre for Disease Prevention and Control.

ECDC: Stockholm; 2022 Mar, 14.

Effectiveness of complete primary vaccination against COVID-19 at primary care and community level during predominant Delta circulation in Europe: multicentre analysis, I-MOVE-COVID-19 and ECDC networks

Kissling E, Hooiveld M, Martínez-Baz, Mazagatos C, William N, Vilcu AM, Kooijman MN, Ilić M, Domegan L, Machado A, de Lusignan S, Lazar M, Meijer A, Brytting M, Casado I, Larrauri A, Murray JL K, Behillil S, de Gier B, Mlinarić I, O’Donnell J, Rodrigues AP, Tsang R, Timnea O, de Lange M, Riess M, Castilla J, Pozo F, Hamilton M, Falchi A, Knol MJ, Kurečić Filipović S, Dunford L, Guiomar R, Cogdale J, Cherciu C Jansen T, Enkirch T, Basile L, Connell J, Gomez V Sandonis Martín V, Bacci S, Rose AMC, Pastore Celentano L, Valenciano M, I-MOVE-COVID-19 and ECDC primary care study teams

July to August 2021. Euro Surveill. 2022;27(21):pii=2101104

European Centre for Disease Prevention and Control. Interim analysis of COVID-19 vaccine effectiveness against Severe Acute Respiratory Infection due to laboratory-confirmed SARS-CoV-2 among individuals aged 65 years and older, ECDC multi-country study.

European Centre for Disease Prevention and Control.

ECDC: Stockholm; 2021 October, 8.

Core protocol for ECDC studies of COVID19 vaccine effectiveness against hospitalisation with Severe Acute Respiratory Infection laboratory-confirmed with SARS-CoV-2, version 1.0. Stockholm: ECDC; 2021 Oct, 8.

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