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Vaccine Effectiveness, Burden and Impact Studies (VEBIS) of COVID-19 and Influenza

Project description

The objectives of the project is to provide technical support to the European Center for Disease Prevention and Control to build an infrastructure to allow regular monitoring of COVID-19 and influenza vaccine effectiveness over time, using a multi-country approach. The VEBIS platform includes vaccine effectiveness studies implemented in different settings.

Context situation

Vaccination plays a key role in the control of the coronavirus disease (COVID-19) pandemic and the lifting of some non-pharmaceutical interventions. Assessment of the real-world performance of the vaccines in the European Union is important to be able to adapt to European vaccination strategies.

Project activities

Hospital network measuring influenza and COVID-19 vaccine effectiveness

Multicentre test-negative design study.

Vaccine effectiveness and impact of COVID-19

vaccines through routinely collected exposure and outcome data using health registries.

COVID-19 vaccine effectiveness against SARS-CoV-2 infection among healthcare workers

Multicentre cohort study.

Primary care network measuring influenza and COVID-19 vaccine effectiveness

Multicentre test-negative design study.



    Scientific publications

    European Center for Disease Prevention and Control. Interim analysis of COVID-19 vaccine effectiveness against Severe Acute Respiratory Infection due to laboratory-confirmed SARS-CoV-2 among individuals aged 20 years and older, ECDC multi-country study – third update

    European Center for Disease Prevention and Control.

    ECDC: Stockholm; 2022 November 8.

    Available here

    European Center for Disease Prevention and Control. Interim analysis of COVID-19 vaccine effectiveness against Severe Acute Respiratory Infection due to laboratory-confirmed SARS-CoV-2 among individuals aged 50 years and older, ECDC multi-country study – first update.

    European Center for Disease Prevention and Control.

    ECDC: Stockholm; 2022 January 20

    Available here

    Estimate of COVID-19 vaccine effectiveness against hospitalization in individuals aged ≥ 65 years using electronic health registries; a pilot study in four EU/EEA countries, October 2021 to March 2022

    Sentis A, Kislaya I, Nicolay N, Meijerink H, Starrfelt J, Martínez-Baz I, Castilla J, Nielsen KF, Hansen CH, Emborg HD, Nardone A, Derrough T, Valenciano M, Nunes B, Monge S, the VEBIS-Lot4 working group

    October 2021 to March 2022. Euro Surveillance. 2022;27(30):pii=2200551

    Available here

    European Center for Disease Prevention and Control. Interim analysis of COVID-19 vaccine effectiveness against Severe Acute Respiratory Infection due to laboratory-confirmed SARS-CoV-2 among individuals aged 30 years and older, ECDC multi-country study – second update.

    European Center for Disease Prevention and Control.

    ECDC: Stockholm; 2022 Mar, 14.

    Available here

    Effectiveness of complete primary vaccination against COVID-19 at primary care and community level during predominant Delta circulation in Europe: multicentre analysis, I-MOVE-COVID-19 and ECDC networks

    Kissling E, Hooiveld M, Martínez-Baz, Mazagatos C, William N, Vilcu AM, Kooijman MN, Ilić M, Domegan L, Machado A, de Lusignan S, Lazar M, Meijer A, Brytting M, Casado I, Larrauri A, Murray JL K, Behillil S, de Gier B, Mlinarić I, O'Donnell J, Rodrigues AP, Tsang R, Timnea O, de Lange M, Riess M, Castilla J, Pozo F, Hamilton M, Falchi A, Knol MJ, Kurečić Filipović S, Dunford L, Guiomar R, Cogdale J, Cherciu C Jansen T, Enkirch T, Basile L, Connell J, Gomez V Sandonis Martín V, Bacci S, Rose AMC, Pastore Celentano L, Valenciano M, I-MOVE-COVID-19 and ECDC primary care study teams

    July to August 2021. Euro Surveillance. 2022;27(21):pii=2101104

    Available here

    European Center for Disease Prevention and Control. Interim analysis of COVID-19 vaccine effectiveness against Severe Acute Respiratory Infection due to laboratory-confirmed SARS-CoV-2 among individuals aged 65 years and older, ECDC multi-country study.

    European Center for Disease Prevention and Control.

    ECDC: Stockholm; 2021 October, 8.

    Available here

    Core protocol for ECDC studies of COVID19 vaccine effectiveness against hospitalization with Severe Acute Respiratory Infection laboratory-confirmed with SARS-CoV-2, version 1.0. Stockholm: ECDC; 2021 Oct, 8.

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